文献类型：期刊文献

英文题名：Tandem C-C/C-N Bond Formation via Rh(III)-Catalyzed α-Fluoroalkenylation and Sequential Annulation of 2-Arylquinazolinones and gem-Difluorostyrenes

作者：Pang, Binghan[1];Wang, Yangyang[1];Hao, Liqiang[1];Wu, Gaorong[1];Ma, Zhihong[2];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China;[2]Biotalk Co LTD, Shanghai 200092, Peoples R China

年份：2023

卷号：88

期号：1

起止页码：143

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20225213315070);WOS:【SCI-EXPANDED(收录号:WOS:000904686500001)，CCR-EXPANDED(收录号:WOS:000904686500001)】；

基金：? ACKNOWLEDGMENTS We gratefully thank the National Natural Science Foundation of China (Project No. 21676088) for financial support.

语种：英文

外文关键词：Catalysis - Hydrated lime - Rhodium compounds - Silver compounds

摘要：An efficient method of Rh(III)-catalyzed coupling reaction between 2-arylquinazolinones and gem-difluorostyrenes has been developed. In this work, two diverse structures of monofluoroalkenes and isoindolo[1,2-b]quinazolin-10(12H)-one derivatives were respectively synthesized by controlling the amount of additives (Ca(OH)2 and AgNTf2) to achieve controlled stepwise breaking of the C-F bonds of gem-difluorostyrenes. This reaction has the characteristics of a wide range of substrates and good functional group tolerance. Meanwhile, several control experiments were conducted and a plausible mechanism was proposed.