文献类型：期刊文献

英文题名：Novel pH-tunable thermoresponsive polymers displaying lower and upper critical solution temperatures

作者：Cai, Xin[1];Zhong, Liang[1];Su, Yue[2];Lin, Shaoliang[3];He, Xiaohua[1]

机构：[1]E China Normal Univ, Sch Chem & Mol Engn, Dept Chem, Shanghai 200241, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Elect Insulat & Thermal Aging, Shanghai 200240, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Adv Polymer Mat Shanghai, Shanghai 200237, Peoples R China

年份：2015

卷号：6

期号：20

起止页码：3875

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20152100861634);WOS:【SCI-EXPANDED(收录号:WOS:000354410300016)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 21174038) and the Projects of Shanghai Municipality (12JC1403102). The Large Instruments Open Foundation of East China Normal University is also appreciated. The authors also thank Prof. Xinyuan Zhu of School of Chemistry & Chemical Engineering, Shanghai Jiao Tong University for help in the experiment of cell viability assay.

语种：英文

外文关键词：Monomers - Synthesis (chemical) - Chemical modification - pH

摘要：Novel pH-tunable thermoresponsive 3-azido-2-hydroxypropyl methacrylate-based polymers displaying lower critical solution temperature (LCST) and upper critical solution temperature (UCST) were successfully synthesized by a combination of atom transfer radical polymerization (ATRP) and a chemical modification reaction. Firstly, a novel monomer dimethyl 3,3'-(((1-(2-hydroxy-3-(methacryloyloxy)propyl)-1H-1,2,3-triazol-4-yl)methyl)azanediyl) dipropanoate (HPMAB) with a hydroxyl group was prepared from 3-azido-2-hydroxypropyl methacrylate (AHPMA) and N, N-bis(3-methoxycarbonyl-ethyl)-propargylamine (BMP) by click chemistry and polymerized via ATRP into a polymer bearing hydroxyl groups, P(HPMAB). Then, P(HPMAB) was subsequently reacted with excess succinic anhydride in the presence of pyridine to yield a polymer bearing carboxyl groups, P(PMAB-COOH). P(HPMAB) and P(PMAB-COOH) exhibited a soluble-insoluble-soluble transition (S-I-S) with LCST from 53.4 to 79.1 degrees C and UCST from 79.4 to 88.3 degrees C in phosphate buffer solutions (PBS) with pH values from 4.7 to 7.8. The pH values in PBS were found to dramatically affect their characteristic thermoresponsive behaviors. As a comparison, a similar functional polymer containing no hydroxyl or carboxyl groups, P(PMAB), was also synthesized by ATRP of the monomer dimethyl 3,3'-(((1-(3-(methacryloyloxy) propyl)-1H-1,2,3-triazol-4-yl)methyl)azanediyl) dipropanoate (PMAB), prepared from 3-azidopropyl methacrylate (APMA) and BMP by click chemistry, and only exhibited a soluble-insoluble transition (S-I) with LCST from 41 to 60 degrees C in PBS with pH values from 4.7 to 7.8. P(HPMAB), P(PMAB-COOH) and P(PMAB) possessed excellent biocompatibility by methyl tetrazolium (MTT) assays against NIH3T3 cells and could be regarded as biomedical materials.