文献类型：期刊文献

英文题名：Transformation of Ginsenosides from Notoginseng by Artificial Gastric Juice Can Increase Cytotoxicity toward Cancer Cells

作者：Wang, Jing-Rong[1,2];Yau, Lee Fong[1];Zhang, Rui[2,3];Xia, Yun[2];Ma, Jing[2];Ho, Hing Man[2];Hu, Ping[3];Hu, Ming[4];Liu, Liang[1];Jiang, Zhi-Hong[1,2]

机构：[1]Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau 00853, Peoples R China;[2]Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China;[3]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[4]Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77030 USA

年份：2014

卷号：62

期号：12

起止页码：2558

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20151500739197);WOS:【SCI-EXPANDED(收录号:WOS:000333551600013)】；

基金：This project is sponsored by Macao Science and Technology Development Fund (066/2011/A3 to W.J.R.).

语种：英文

外文关键词：notoginseng; ginsenoside; gastric juice; transformation; LC-MS

摘要：Multicomponent metabolic profile of notoginseng saponins in artificial gastric juice was qualitatively and quantitatively investigated, showing that ginsenosides were transformed via multiple pathways including deglycosylation, dehydration, hydration, and oxygenation. A total of 83 metabolites was identified by using UPLC-QTOF-MS, among which 16 new dammarane glycosides were further characterized by comparing with synthesized authentic compounds. Transformation time-course of notoginseng saponins in artificial gastric juice was quantitatively measured for the first time, showing rapid degradation of primary ginsenosides and concomitant formation of deglycosylation, hydration, and dehydration products. It was further demonstrated that the resultant metabolites exhibited enhanced cytotoxicity toward cancer cells. The extensive metabolism of ginsenosides within a transit time span in stomach, together with the formation of metabolites with diversified chemical structures possessing enhanced biological activities, indicated an important role of transformation in gastric juice in the systematic effects of ginsenosides.