文献类型：期刊文献

英文题名：Direct flipping dynamics and quantized enrichment of chirality at single-molecule resolution

作者：Hu, Weilin[1];Zhang, Zhiyun[2];Xiong, Wan[3,4];Li, Mingyao[1];Yan, Yong[1,5,6];Yang, Caiyao[1];Zou, Qi[2];Lu, Jing-Tao[3,4];Tian, He[2];Guo, Xuefeng[1,7]

机构：[1]Peking Univ, Coll Chem & Mol Engn, Natl Biomed Imaging Ctr, Beijing Natl Lab Mol Sci, 292 Chengfu Rd, Beijing 100871, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Adv Mat & Feringa Nobel Prize Scientist Jo, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Huazhong Univ Sci & Technol, Inst Quantum Sci & Engn, Sch Phys, 1037 Luoyu Rd, Wuhan 430074, Peoples R China;[4]Huazhong Univ Sci & Technol, Wuhan Natl High Magnet Field Ctr, 1037 Luoyu Rd, Wuhan 430074, Peoples R China;[5]Nanjing Univ Posts & Telecommun, Ctr Mol Syst & Organ Devices, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China;[6]Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210023, Peoples R China;[7]Nankai Univ, Coll Elect Informat & Opt Engn, Frontiers Sci Ctr New Organ Matter, Ctr Single Mol Sci,Inst Modern Opt, 38 Tongyan Rd, Tianjin 300350, Peoples R China

年份：2024

卷号：10

期号：28

外文期刊名：SCIENCE ADVANCES

收录：;EI(收录号：20242916718165);WOS:【SCI-EXPANDED(收录号:WOS:001280155200004)】；

基金：We acknowledge primary financial supports from the National Key R&D Program of China (2021YFA1200101 and 2022YFE0128700 to X.G.), the National Natural Science Foundation of China (21933001, 21727806, and 22150013 to X.G.; 21790361, 22335004, and 22175064 to Q.Z.; and 22273029 to J.-T.L.), Shanghai Municipal Sci. & Tech. Major Project (2018SHZDZX03 to Q.Z.), the Tencent Foundation through the XPLORER PRIZE (to X.G.), "Frontiers Science Centre for New Organic Matter" at Nankai University (63181206 to X.G.), and the Natural Science Foundation of Beijing (2222009 to X.G.).

语种：英文

外文关键词：Amines - Graphene - Graphene devices - Molecules - Stereochemistry

摘要：Chirality is an important aspect of nature, and numerous macroscopic methods have been developed to understand and control chirality. For the chiral tertiary amines, their flexible flipping process makes it possible to achieve high chiral controllability without bond formation and breaking. Here, we present a type of stable chiral single-molecule devices formed by tertiary amines, using graphene-molecule-graphene single-molecule junctions. These single-molecule devices allow real-time, in situ, and long-time measurements of the flipping process of an individual chiral nitrogen center with high temporal resolution. Temperature- and bias voltage-dependent experiments, along with theoretical investigations, revealed diverse chiral intermediates, indicating the regulation of the flipping dynamics by energy-related factors. Angle-dependent measurements further demonstrated efficient enrichment of chiral states using linearly polarized light by a symmetry-related factor. This approach offers a reliable means for understanding the chirality's origin, elucidating microscopic chirality regulation mechanisms, and aiding in the design of effective drugs.