文献类型：期刊文献

英文题名：Organomolecular Ferroelectric Nanocatalyst Augments Tumor Immunotherapy by Inducing Apoptosis and Ferroptosis

作者：Xu, Huning[1];Qiao, Xiaohui[1];Liang, Jing[1];Qiu, Luping[1];Xue, Liyun[1];Fang, Yan[1];Xiang, Huijing[2];Li, Xingguang[3];Chen, Yu[2];Ding, Hong[1]

机构：[1]Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Dept Ultrasound, Shanghai 200040, Peoples R China;[2]Shanghai Univ, Sch Life Sci, Materdicine Lab, Shanghai 200444, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2025

卷号：37

期号：15

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20250917956807);WOS:【SCI-EXPANDED(收录号:WOS:001430285500001)】；

基金：H.N.X. and X.H.Q. contributed equally to this work. The authors greatly acknowledge the final support of the National Natural Science Foundation of China (Grant Nos. 82272017 and 32171391), the National Science Fund for Excellent Young Scholars (Grant No. T2322018), the National Natural Science Fund for Young Scholars (Grant Nos. 82102050, 82202185, and 82302217), Shanghai Science and Technology Development Fund (Grant No. 22Y11911500), Shanghai Shuguang Program (Grant No. 21SG39), Shanghai Science and Technology Program (Grant No. 21010500100), Shanghai Rising-Star Program (Grant No. 22QA1403600), Key Science and Technology Research and Development Projects of Jiangxi Province (Grant No. 20223BBH80014) and Innovative research team of high-level local universities in Shanghai.

语种：英文

外文关键词：apoptosis; catalytic nanomedicine; ferroptosis; molecular ferroelectrics; tumor immunotherapy

摘要：Immunogenic programmed cell death effectively triggers acute inflammatory responses, thereby enhancing antitumor immunity. The advancement of biodegradable nonmetallic dual inducers represents a promising strategy. Herein, a biodegradable organomolecular ferroelectric nanoplatform (C-60-TCNQ, CT) is designed to facilitate effective ferroelectric catalysis, thereby augmenting tumor immunotherapy through apoptosis and ferroptosis. CT-mediated ultrasound-triggered ferroelectric catalysis promotes ferroelectric polarization and significantly increases the production of reactive oxygen species, leading to substantial tumor cell apoptosis. Moreover, the polycyano group of CT nanoparticles selectively reacts with cysteine under mild conditions, resulting in redox imbalances and the accumulation of lipid peroxides, which contribute to the induction of ferroptosis in tumor cells. Additionally, the apoptosis and ferroptosis induced by CT stimulate immunogenic cell death progression, eliciting robust immune responses. In vivo evaluation using a bilateral tumor model demonstrates the capacity of CT to sensitize anti-PD-L1 therapy under ultrasound irradiation, achieving an impressive antitumor response rate of 96.2% against malignant melanoma and an 80% inhibition of tumor metastasis. RNA sequencing analysis revealed that treatment with CT resulted in a downregulation of gene signatures associated with the immune-related Jak-Stat signaling pathway. This study opens a novel avenue to developing organomolecular ferroelectric nanomedicines for effective tumor immunotherapy.