文献类型：期刊文献

英文题名：Recent advances in the anti-aging effects of natural polysaccharides: Sources, structural characterization, action mechanisms and structure-activity relationships

作者：Teng, Hao[1,2];Xiao, Huanhuan[3];Li, Xueying[3];Huang, Jin[4];Zhang, Bin[1];Zeng, Minghua[1]

机构：[1]Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China;[2]Guilin Tourism Univ, Sch Food & Hlth, Guilin 541006, Peoples R China;[3]Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China;[4]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

年份：2025

卷号：160

外文期刊名：TRENDS IN FOOD SCIENCE & TECHNOLOGY

收录：;EI(收录号：20251618270105);WOS:【SCI-EXPANDED(收录号:WOS:001489774600001)】；

基金：This work was supported by the BAGUI talent program (No. 2019AC26001) , the Natural Science Foundation of China (No. U23A2080, 22371173, and 22171075) , and the Natural Science Foun-dation of Guangxi Province of China (No. 2023GXNSFBA026322) .

语种：英文

外文关键词：Polysaccharides; Anti-aging effect; Sources; Structural characterization; Mechanisms; Structure-activity relationships

摘要：Background: The global aging process continues to intensify, resulting in increased morbidity, mortality and escalating health-care costs worldwide. Conventional pharmaceuticals used in the treatment of aging and agerelated diseases face several challenges, including low bioavailability, high costs, and significant side effects. Polysaccharides derived from natural resources garnered attention in anti-aging research, owing to their abundant and diverse sources, favorable safety profiles, minimal side effects and consistent efficacy. Current investigations on anti-aging polysaccharides remain deficient in holistically elucidating the phylogenetic source diversity, multi-level regulation mechanisms, and structural-activity relationships. Scope and approach: This review summarizes the sources, structural characterization and action mechanisms of natural polysaccharides with anti-aging properties, and highlights their potential for aging intervention and as anti-aging dietary supplements. Moreover, the structure-activity relationships of anti-aging polysaccharides are discussed. Finally, the current challenges of anti-aging research on natural polysaccharides and their future research directions are proposed. Key findings and conclusions: Natural polysaccharides with anti-aging effects are primarily sourced from plants, algae, and fungi, with their bioactivities mediated through diverse regulatory mechanisms. Despite the diversity in biological sources of anti-aging polysaccharides, some exhibit shared structural characteristics and analogous mechanisms of action. Natural polysaccharides exhibit significant potential in the field of anti-aging research. This review synthesizes various sources, elucidates the intricate regulatory mechanisms, and delineates