文献类型：期刊文献

英文题名：Reliable sizing-up of the 3D curved circular microchannel reactor for continuous flow synthesis of a zidovudine intermediate

作者：Yan, Haohui[1];Chen, Yan[1];Liu, Peiwen[1];Zhu, Weiping[1,2];Zhao, Fang[3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：9

期号：10

起止页码：2750

外文期刊名：REACTION CHEMISTRY & ENGINEERING

收录：;EI(收录号：20243316876023);WOS:【SCI-EXPANDED(收录号:WOS:001286031300001)】；

基金：This work was supported by the National Key Research and Development Program of China (No. 2023YFD1700303), the National Natural Science Foundation of China (No. 21808059, 21878088, and 21476077), and the Key Project of the Shanghai Science and Technology Committee (No. 18DZ1112703).

语种：英文

外文关键词：Chemical reactors - Computational fluid dynamics - Energy dissipation - Heat transfer - Microchannels - Two phase flow

摘要：Herein, we report a size scale-up method for a 3D curved circular microchannel reactor (3D-CCMR), based on a rule of keeping fluid velocity and residence time constant during sizing-up and validated via computational fluid dynamics simulation with mixing index as the key evaluation indicator. The energy dissipation rate was also investigated via simulation to evaluate the energy consumption during sizing-up. Then, a scaled-up microreactor (3D-CCMR-2), aiming at a throughput scale-up factor of 4, was manufactured, and it was proved experimentally that the mass and heat transfer performance was not deteriorated in 3D-CCMR-2 as compared to the original microreactor (3D-CCMR-1). Ultimately, the continuous flow synthesis of the intermediate of anti-AIDS drug zidovudine was performed in both 3D-CCMRs and an actual throughput scale-up factor of 4.0 was achieved. The work in this paper represents the first key step for the scale-up of continuous flow synthesis of zidovudine, and the sizing-up strategy proposed in this paper could offer good guidelines for the size scale-up of microreactors. We established a sizing-up strategy for a 3D curved circular microchannel reactor. A scaled-up microreactor was developed and the productivity of the zidovudine intermediate was quadrupled.