文献类型：期刊文献

英文题名：Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel

作者：Zhang, Jian[1];Zheng, Yongjun[2,3];Lee, Jimmy[1];Hoover, Alex[1];King, Sarah Ann[1];Chen, Lifeng[4];Zhao, Jing[1];Lin, Qiuning[5];Yu, Cunjiang[6,7,8];Zhu, Linyong[2,4];Wu, Xiaoyang[1]

机构：[1]Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat Joint Int Res Lab Precis Chem & Mo, Shanghai 200237, Peoples R China;[3]Burns Ctr Changhai Hosp, Shanghai, Peoples R China;[4]Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL USA;[5]Shanghai Jiao Tong Univ, Sch Biomed Engn, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;[6]Penn State Univ, Mat Res Inst, Dept Engn Sci & Mech, University Pk, PA 16802 USA;[7]Penn State Univ, Mat Res Inst, Dept Biomed Engn, University Pk, PA 16802 USA;[8]Penn State Univ, Mat Res Inst, Dept Mat Sci & Engn, University Pk, PA 16802 USA

年份：2023

卷号：10

期号：7

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20230313403711);WOS:【SCI-EXPANDED(收录号:WOS:000914191300001)】；

基金：The authors thank Dr. Elaine Fuchs at the Rockefeller University for sharing reagents. The authors also thank Linda Degenstein from the University of Chicago transgenic core facility for her excellent technical assistance. The animal studies were carried out in the ALAAC-accredited animal research facility at the University of Chicago. This work was supported by grants R01 OD023700, R01 DA047785, R21 AA027172, and R01AR78555 to X.W. from The National Institutes of Health, Diabetes Research Connection (DRC) fellowship to J.Z., and the National Natural Science Foundation of China (Grant Nos. 22022506) to Q.L.

语种：英文

外文关键词：boronic hydrogel; diabetes; fluorescent nanodiamond; glucose; microneedle

摘要：Continuous monitoring of glucose allows diabetic patients to better maintain blood glucose level by altering insulin dosage or diet according to prevailing glucose values and thus to prevent potential hyperglycemia and hypoglycemia. However, current continuous glucose monitoring (CGM) relies mostly on enzyme electrodes or micro-dialysis probes, which suffer from insufficient stability, susceptibility to corrosion of electrodes, weak or inconsistent correlation, and inevitable interference. A fluorescence-based glucose sensor in the skin will likely be more stable, have improved sensitivity, and can resolve the issues of electrochemical interference from the tissue. This study develops a fluorescent nanodiamond boronic hydrogel system in porous microneedles for CGM. Fluorescent nanodiamond is one of the most photostable fluorophores with superior biocompatibility. When surface functionalized, the fluorescent nanodiamond can integrate with boronic polymer and form a hydrogel, which can produce fluorescent signals in response to environmental glucose concentration. In this proof-of-concept study, the strategy for building a miniatured device with fluorescent nanodiamond hydrogel is developed. The device demonstrates remarkable long-term photo and signal stability in vivo with both small and large animal models. This study presents a new strategy of fluorescence based CGM toward treatment and control of diabetes.