文献类型：期刊文献

英文题名：Fast and Convenient Synthesis of Amine-Terminated Polylactide as a Macroinitiator for ω-Benzyloxycarbonyl-L-Lysine-N-Carboxyanhydrides

作者：Ju, Mingjie[1];Gong, Feirong[1];Cheng, Shujun[1];Gao, Yun[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2011

卷号：2011

外文期刊名：INTERNATIONAL JOURNAL OF POLYMER SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000307633400015)】；

基金：The authors would like to thank the National Basic Research Program of China (no. 81000105) for the financial support to this work.

语种：英文

摘要：Amine-terminated poly (L-lactide) (NH2-PLLA) with various chain lengths were successfully synthesized by sequential tert-butyl-N-(3-hydroxypropyl) carbamate initiated bulk ring-opening polymerization (ROP) of L-lactide (L-LA) in the presence of Stannous(II) 2-ethylhexanoate (Sn(Oct)(2)) and deprotection of the N-tert-butoxycarbonyl (Boc) group at the end of the polymer chain. The polymers obtained were characterized by FT-IR, H-1 NMR, and GPC method. NH2-PLLA thus prepared was used to initiate the polymerization of omega-benzyloxycarbonyl-L-lysine-N-carboxyanhydride (Lys (Z)-NCA), and the result confirmed the high nucleophilicity of the terminal amine group. This method was not only suitable for the preparation of low molecular weight NH2-PLLA, but also quite efficient in the synthesis of high molecular weight samples.