文献类型：期刊文献

中文题名：Novel Total Synthesis of Mansouramycin B

英文题名：Novel Total Synthesis of Mansouramycin B

作者：Yi Zhang[1];Xiaoxin Shi[1];Tianzhuo Meng[1];Qiqi Fan[1];Xia Lu[1]

机构：[1]Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

年份：2016

卷号：34

期号：7

起止页码：683

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；

基金：the National Natural Science Foundation of China （No. 20972048） for the financial support of this work.

语种：英文

中文关键词：Mansouramycin B;total synthesis;isoquinoline;quinone;alkaloid;salicylaldehyde

外文关键词：Mansouramycin B, total synthesis, isoquinoline, quinone, alkaloid, salicylaldehyde

摘要：A novel total synthesis of Mansouramycin B （1） was performed via 10 steps in 28% overall yield starting from the readily available and cheap salicylaldehyde. Two key steps of this total synthesis are noteworthy. The first one is base-promoted one-pot aerobic aromatization of N-tosyltetrahydroisoquinoline 6, the second one is oxidation of 5-hydroxy-3-methyl-isoquinoline 8 with iodobenzene diacetate [PhI（OAc）2].
A novel total synthesis of Mansouramycin B （1） was performed via 10 steps in 28% overall yield starting from the readily available and cheap salicylaldehyde. Two key steps of this total synthesis are noteworthy. The first one is base-promoted one-pot aerobic aromatization of N-tosyltetrahydroisoquinoline 6, the second one is oxidation of 5-hydroxy-3-methyl-isoquinoline 8 with iodobenzene diacetate [PhI（OAc）2].