文献类型：期刊文献

英文题名：Enhancing Photodynamic Therapy Efficacy by Using Fluorinated Nanoplatform

作者：Que, Yurong[1];Liu, Yajing[2];Tan, Wei[1];Feng, Chun[1];Shi, Ping[2];Li, Yongjun[1];XiaoyuHuang[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, 345 Lingling Rd, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：5

期号：2

起止页码：168

外文期刊名：ACS MACRO LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000370576000003)】；

基金：The authors thank the financial support from National Basic Research Program of China (201SCB931900), National Natural Science Foundation of China (21504102 and 21474127), and Shanghai Scientific and Technological Innovation Project (13ZR1464800, 14JC1493400, 14QA1404500, and 14520720100).

语种：英文

摘要：Photodynamic therapy (PDT) is a noninvasive therapeutic modality with fast healing process and little or no scarring. The production of reactive oxygen species is highly dependent on oxygen concentration, and thus, the therapeutic efficacy of PDT would be retarded by inefficient oxygen supply in hypoxic tumor cell and the oxygen self-consuming mechanism of PDT. It is well-known that perfluorocarbons are endowed with properties of enhanced oxygen solubility and transfer capacity. Herein, we prepared a series of nanoplatforms of spherical micelles with different ratios of pentafluorophenyl to porphyrin in the core and utilized these micelles as models to examine the influence of content of fluorinated segments on the PDT effect of porphyrins. It was found for the first time, as far as we are aware, that the production efficacy of singlet oxygen increased with the rising in the ratio of pentafluorophenyl to porphyrin. Thus, this work presents a new avenue to improve PDT efficacy by enhancing oxygen solubility and diffusivity of nanoplatforms with the incorporation of perfluorocarbon segments.