文献类型：期刊文献

英文题名：Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties

作者：Sedgwick, Adam C.[1];Yan, Kai-Cheng[2,3];Mangel, Daniel N.[1];Shang, Ying[2,3];Steinbrueck, Axel[1];Han, Hai-Hao[2,3];Brewster, James T., II[1];Hu, Xi-Le[2,3];Snelson, Dylan W.[1];Lynch, Vincent M.[1];Tian, He[2,3];He, Xiao-Peng[2,3];Sessler, Jonathan L.[1]

机构：[1]Univ Texas Austin, Dept Chem, Austin, TX 78712 USA;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, Shanghai 200237, Peoples R China

年份：2021

卷号：143

期号：3

起止页码：1278

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20210509846288);WOS:【SCI-EXPANDED(收录号:WOS:000614064400004)】；

基金：The authors thank the National Natural Science Foundation of China (Nos. 21788102, 91853201, 21722801, 81673489, and 31871414), the National Science and Technology Major Project of China (No. 2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), and the Fundamental Research Funds for the Central Universities (222201717003) for financial support. Initial work in Austin was supported by the National Institutes of Health (R01 GM103790 to J.L.S.) and subsequently by the Robert A. Welch Foundation (F-0018).

语种：英文

外文关键词：Chelation - Diagnosis - Fluorescence - Iron - Charge transfer - Scaffolds (biology) - Scaffolds - Phosphatases

摘要：Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.