文献类型：期刊文献

英文题名：Formation of a novel Cu-containing bioactive glass nano-topography coating with strong bactericidal capability and bone regeneration

作者：Huo, Shicheng[1];Lyu, Zhuocheng[2];Su, Xinjin[3];Wang, Fan[7];Liu, Jia[1];Liu, Shu[1];Liu, Xuesong[8];Bao, Xiaogang[1];Zhang, Jue[6];Zheng, Kai[4,5];Xu, Guohua[1]

机构：[1]Navy Med Univ, Changzheng Hosp, Spine Ctr, Dept Orthoped Surg, Shanghai 200003, Peoples R China;[2]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg,Dept Orthoped, Shanghai 200127, Peoples R China;[3]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Spine Surg, Shanghai 200127, Peoples R China;[4]Nanjing Med Univ, Jiangsu Prov Engn Res Ctr Stomatol Translat Med, Nanjing 210029, Peoples R China;[5]Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Nanjing 210029, Peoples R China;[6]Wannan Med Coll Wuhu, Oral Dis Res Ctr, Sch Stomatol, Wuhu 241000, Peoples R China;[7]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[8]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Rheumatol, 145 Middle Shandong Rd, Shanghai 200001, Peoples R China

年份：2023

卷号：253

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20230513458379);WOS:【SCI-EXPANDED(收录号:WOS:000992920400001)】；

基金：Shicheng Huo, Zhuocheng Lyu, and Xinjin Su contributed equally to this work. This work was supported by a research grant from the National Natural Foundation of China (No.8197090186) , Shanghai Committee of Science and Technology (201409003700) , Shanghai Sailing Program (Grant No. 21YF1458200) , Shanghai Changzheng Hospital Program (Grant No. 2019CZJS104) , the National Natural Science Foundation of China (Grant No. 81972076) , and Shanghai Sailing Program 22YF1424000.

语种：英文

外文关键词：Electrophoretic deposition; Copper; Immunomodulation; Antibacterial; Osseointegration

摘要：Implant-related infection (IRI) is a disastrous complication after total joint arthroplasty (TJA). Due to its cyto-compatibility and mechanically resistance, titanium (Ti) has been recognized as suitable bone implant materials. However, Ti lacks bioactivity and is vulnerable to bacterial infection. In this study, we developed an innovative surface coating using electrophoretic deposition (EPD) to overcome those limitations. The coating was composed of (i) a natural biocompatibility polymer Chitosan (Chit), and (ii) a novel copper-doped bioactive glass nano -particles (Cu-BGNs) with antibacterial and pro-osteogenic properties. In vitro experiments showed that this coating endowed the Ti surface with the ability to promote macrophage M1 polarization through topography cues and released copper ions. The coating combining immunoregulatory antibacterial effects with transient bactericidal activity led to synergetic effects against IRIs. Furthermore, the coated Ti implants exerted favorable osteo-immunomodulatory effects towards enhanced osteogenic abilities as evidenced in vitro and in vivo. This strategy combining Cu-BGNs-Chit composites and EPD provides novel strategies for designing and fabricating immunomodulatory implants targeting IRIs.