文献类型：期刊文献

英文题名：Enantioselective Mannich reaction between rhodanines and isatin-derived ketimines to construct vicinal tetrasubstituted stereocenters

作者：Xu, Han;Kang, Tian-Chen;Sha, Feng;Wu, Xin-Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2018

卷号：16

期号：32

起止页码：5780

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20183405709624);WOS:【SCI-EXPANDED(收录号:WOS:000441765600006)，CCR-EXPANDED(收录号:WOS:000441765600006)】；

基金：We are grateful for the financial support from Science and Technology Commission of Shanghai Municipality (15ZR1409200).

语种：英文

外文关键词：Stereoselectivity - Amines - Catalysts

摘要：An organocatalytic enantioselective Mannich reaction between rhodanines and isatin-derived ketimines was developed. With 2 mol% of a quinine-based tertiary amine-thiourea catalyst C2, 3,3-disubstituted oxindoles with vicinal tetrasubstituted stereocenters were obtained in moderate-to-excellent yields (43-99%) with excellent diastereoselectivities (98 : 2-99 : 1 dr) and good-to-excellent enantioselectivities (up to 97% ee). The readily available substrates, low catalyst loading and high stereoselectivity are the major features.