文献类型：期刊文献

英文题名：Surface Modification-Complexation Strategy for Cisplatin Loading in Mesoporous Nanoparticles

作者：Gu, Jinlou[1];Su, Shasha[1];Li, Yongsheng[1];He, Qianjun[2];Zhong, Flaying[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2010

卷号：1

期号：24

起止页码：3446

外文期刊名：JOURNAL OF PHYSICAL CHEMISTRY LETTERS

收录：;EI(收录号：20105113511243);WOS:【SCI-EXPANDED(收录号:WOS:000285446800005)】；

基金：This work was financially supported by the Shanghai Pujiang Program (No. 09PJ1403000), the Research Fund for the Doctoral Program of Higher Education (No. 20090074120009), and the Natural Science Foundation of China (No. 51072053).

语种：英文

外文关键词：Drug delivery - Surface treatment - Lanthanum compounds

摘要：High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.