文献类型：期刊文献

英文题名：Superstable and Large-Scalable Organosilica-Micellar Hybrid Nanosystem via a Confined Gelation Strategy for Ultrahigh-Dosage Chemotherapy

作者：Niu, Dechao[1];He, Jianping[1];Qin, Xing[1];Liu, Yu[2,3];Liu, Honglai[2,3];Hu, Ping[4];Li, Yongsheng[1,5];Shi, Jianlin[1,4]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Sch Mat Sci & Engn, Low Dimens Mat Chem Lab,Key Lab Ultrafine Mat,Min, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China;[5]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2021

卷号：21

期号：22

起止页码：9388

外文期刊名：NANO LETTERS

收录：;EI(收录号：20214811227677);WOS:【SCI-EXPANDED(收录号:WOS:000756421600004)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002); The National Natural Science Foundation of China (Nos. 52072124 and 51972112); Shanghai Municipal Science and Technology Major Project (grant 2018SHZDZX03); Natural Science Foundation of Shanghai (No. 20ZR1414900); Leading talents in Shanghai in 2018; and The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the 111 project (B14018).

语种：英文

外文关键词：confined gelation; large-scale production; organosilica; glutathione-responsive; tumor specific chemotherapy

摘要：Although various drug nanocarriers have been developed for treating solid tumors, their clinical transformation is greatly limited by the difficulties in quantity production and unpredictable in vivo toxic effects. Herein, a facile "confined-gelation" strategy is developed to quantity-produce intelligent pluronic organosilica micelles (designated as IPOMs) with an undetectable critical micelle concentration (CMC), which features the self-assembly induced core confinement by block copolymers, the inner hydrolysis-condensation of silane to the oligomer skeleton, and oxidative cross-linking of disulfide skeleton to core gelation. The docetaxel-loaded IPOMs (DTX@IPOMs) with precise glutathione (GSH) responsiveness not only display an ultrahigh tolerated dose (360 mg/kg) in healthy Kunming mice model but also exhibit a remarkable tumor inhibition efficacy in both subcutaneous and orthotopic mice tumor models upon an extraordinarily large dosage (50 mg/kg). The present confined-gelation strategy provides a novel pathway to design and quantity-produce low-toxic and high-efficacy organic-inorganic hybrid nanodrugs in future clinical transformations.