文献类型：期刊文献

英文题名：Recent advances in the synthesis and C-F functionalization of gem-difluoroalkenes

作者：Zhang, Xuxue[1];Cao, Song[1]

机构：[1]ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2017

卷号：58

期号：5

起止页码：375

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000392776000001)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21472043 and 21272070).

语种：英文

外文关键词：gem-Difluoroalkenes; Synthesis; New reactions; C-F functionalization

摘要：The gem-difluoroalkenes and related compounds have gained much attention from the organic synthetic community due to their widespread applications as versatile fluorinated building blocks for the synthesis of pharmaceuticals, agrochemicals and functional materials. In the past two decades, significant progress has been made to the development of efficient methods for the construction of gem-difluoroalkenes and useful reactions involving the cleavage of C-F bond in gem-difluoroalkenes. In this Digest review, these advances in the synthesis and reaction chemistry of gem-difluoroalkenes are summarized, with special emphasis placed on novel synthetic applications of them in recent ten years. (C) 2016 Elsevier Ltd. All rights reserved.