文献类型：期刊文献

中文题名：Synthesis of Trisubstituted Isoxazoles from Nitroenamines and Aromatic Aldehydes

英文题名：Synthesis of Trisubstituted Isoxazoles from Nitroenamines and Aromatic Aldehydes

作者：Chao Lei[1];Zhenhong Gao[1];Xusheng Shao[1];Xiaoyong Xu[1];Zhong Li[1,2]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;[2]Shanghai Collaborative Innovation Center for Biomanufaeturing Technology, Shanghai 200237, China

年份：2017

卷号：35

期号：10

起止页码：1517

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2017_2018】；

语种：英文

中文关键词：isoxazoles;nitroenamines;denitration;heterocycles;synthetic methods

外文关键词：isoxazoles, nitroenamines, denitration, heterocycles, synthetic methods

摘要：A novel approach for the synthesis of trisubstituted isoxazoles from nitroenamines and aromatic aldehydes is developed. L-Proline/potassium carbonate system was employed to promote this process. The reaction underwent nucleophilic attack of nitroenamines to aromatic aldehydes, intramolecular denitration, tautomerization and elimination of H2O to furnish the target compounds.
A novel approach for the synthesis of trisubstituted isoxazoles from nitroenamines and aromatic aldehydes is developed. L-Proline/potassium carbonate system was employed to promote this process. The reaction underwent nucleophilic attack of nitroenamines to aromatic aldehydes, intramolecular denitration, tautomerization and elimination of H2O to furnish the target compounds.