文献类型：期刊文献

英文题名：Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy

作者：Shi, Ben[1,2];Yan, Qinglong[3];Tang, Jie[1,2];Cin, Kai[1,2];Zhang, Jichao[3];Zhu, Ying[3];Xu, Ge[1,2];Wang, Rongchen[1,2];Chen, Jian[1,2];Gao, Wei[1,2];Zhu, Tianli[1,2];Shi, Jiye[3];Fan, Chunhai[3];Zhao, Chunchang[1,2,4,5];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Div Phys Biol & Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China;[5]Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China

年份：2018

卷号：18

期号：10

起止页码：6411

外文期刊名：NANO LETTERS

收录：;EI(收录号：20184005899241);WOS:【SCI-EXPANDED(收录号:WOS:000447355400042)】；

基金：We gratefully acknowledge the financial support by the National Key R&D Program of China (2016YFA0400900), National Science Foundation of China (grant numbers 21672062, 11675251, 21390414), and the Key Research Program of Frontier Sciences, CAS (Grant NO. QYZDJ-SSW-SLH031).

语种：英文

外文关键词：Nanostructured photothermal agent; hydrogen sulfide; activatable; theranostic; NIR-II fluorescence; tumor-specific

摘要：Near-infrared (NIR)-II fluorescence agents hold great promise for deep-tissue photothermal therapy (PTT) of cancers, which nevertheless remains restricted by the inherent nonspecificity and toxicity of PTT. In response to this challenge, we herein develop a hydrogen sulfide (H2S)-activatable nanostructured photothermal agent (Nano-PT) for site-specific NIR-II fluorescence-guided PTT of colorectal cancer (CRC). Our in vivo studies reveal that this theranostic Nano-PT probe is specifically activated in H2S-rich CRC tissues, whereas it is nonfunctional in normal tissues. Activation of Nano-PT not only emits NIR-II fluorescence with deeper tissue penetration ability than conventional fluorescent probes but also generates high NIR absorption resulting in efficient photothermal conversion under NIR laser irradiation. Importantly, we establish NIR-II imaging-guided PTT of CRC by applying the Nano-PT agent in tumor-bearing mice, which results in complete tumor regression with minimal nonspecific damages. Our studies thus shed light on the development of cancer biomarker-activated PTT for precision medicine.