文献类型：期刊文献

英文题名：Stem cell differentiation mediated by biomaterials/surfaces

作者：He, Hongyan[1]; Liu, Changsheng[1]

机构：[1] School of Material Science and Engineering, East China University of Science and Technology, Shanghai, China

年份：2016

起止页码：187

外文期刊名：Polymeric Biomaterials for Tissue Regeneration: From Surface/Interface Design to 3D Constructs

收录：EI(收录号：20182705438740)

语种：英文

外文关键词：Cell proliferation - Bone

摘要：Directing the differentiation of stem cells into a specific stromal lineage is an important step for medical uses. However, the uncontrolled and inefficient proliferative and differentiation behaviors of stem cells are still the significant challenges. Since the stem cell fate is strongly determined by the characteristics of the microenvironment in vitro, the biomaterials/surfaces constructs with artificial structures could offer the several regulation cues to modulate the cellular proliferation, and most importantly lineage particular differentiation. Furthermore, adding growth components existing in the ECM holds the potential for guiding the stem cell fate. Therefore, this chapter aims to provide an update on the influencing cues that are being explored to govern stem cell fate, with a focus on the differentiation of bone-marrow-derived MSCs. ? 2016 Springer Science+Business Media Singapore.