文献类型：期刊文献

中文题名：手性溶剂萃取麻黄碱差向异构体

英文题名：SOLVENT EXTRACTION OF EPHEDRINE EPIMERIDES WITH CHIRAL AGENTS

作者：岑仲浙[1];蔡水洪[1]

机构：[1]华东理工大学化工学院,上海200237

年份：2000

卷号：51

期号：3

起止页码：418

中文期刊名：化工学报

外文期刊名：CIESC Journal

收录：CSTPCD;;Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金!资助项目 (No .2 97760 1 6)

语种：中文

中文关键词：萃取;拆分;差向异构体;麻黄碱;手性化合物;制药

外文关键词：extraction, resolution, epimeride, ephedrine, tartrate diester

摘要：In this work six kinds of tartrate diesters were prepared from D(-), L(+) or DL-tartaric acid respectively, and their structure were verified by IR and NMR. The extraction behavior of optical compounds, D(-) ephedrine and L(+) pseudoephedrine, was investigated at room temperature using prepared tartrate diester as extracting agent and n -heptane as diluent. The ratio of tartrate diester and n -heptane is 1∶1. Distribution coefficients, obtained from experiment data by material balance, show that there is a chiral recognition: L(+) tartrate diesters favour extraction of L(+) pseudoephedrine,while D(-) tartrate diesters favour extraction of D(-) ephedrine. The extraction behavior of the mixture of the above optical active epimerides, was also investigated under the same experimental conditions. The experiment data with HPLC also showed the same conclusion. Meanwhile, a blank experiment was carried out and the result showed that there was no evident effect on extraction distribution coefficients when extraction process occurred in the presence of n -heptane. The relationship between the structure of extracting agent and optical activity of the epimerides was also discussed.
In this work six kinds of tartrate diesters were prepared from D(-), L(+) or DL-tartaric acid respectively, and their structure were verified by IR and NMR. The extraction behavior of optical compounds, D(-) ephedrine and L(+) pseudoephedrine, was investigated at room temperature using prepared tartrate diester as extracting agent and n -heptane as diluent. The ratio of tartrate diester and n -heptane is 1∶1. Distribution coefficients, obtained from experiment data by material balance, show that there is a chiral recognition: L(+) tartrate diesters favour extraction of L(+) pseudoephedrine,while D(-) tartrate diesters favour extraction of D(-) ephedrine. The extraction behavior of the mixture of the above optical active epimerides, was also investigated under the same experimental conditions. The experiment data with HPLC also showed the same conclusion. Meanwhile, a blank experiment was carried out and the result showed that there was no evident effect on extraction distribution coefficients when extraction process occurred in the presence of n -heptane. The relationship between the structure of extracting agent and optical activity of the epimerides was also discussed.