文献类型：期刊文献

英文题名：Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

作者：Yang, Shunping[1];Wu, Yanfang[1];Zhang, Hao[1];Sun, Jin[1];Liu, Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2021

卷号：66

期号：5

起止页码：2022

外文期刊名：JOURNAL OF CHEMICAL AND ENGINEERING DATA

收录：;EI(收录号：20211810303275);WOS:【SCI-EXPANDED(收录号:WOS:000651784600017)】；

语种：英文

外文关键词：Propanol - Organic solvents - Acetone

摘要：Ticagrelor (TCG) is a P2Y(12) platelet inhibitor and has several crystal forms including Form II and Form V. In this work, it has been confirmed that Form II TCG would gradually transform to Form V in selected solvents. According to the crystal form stability, a dynamic method was adopted to measure the solubility of Form II TCG in six pure solvents (n-propanol, isopropanol, n-butanol, 2-butanol, ethyl acetate, and isopropyl acetate). The solubility of Form V TCG in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, and cyclohexanone) was measured by a static method. The solubility measurement temperature range was from 273.15 to 313.15 K. The experimental solubility data were correlated by the modified Apelblat model and the lambda h model. It was shown that the calculated solubility was consistent with the experimental data.