文献类型：期刊文献

英文题名：Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release

作者：Chen, Chao[1];Sun, Wen[1];Wang, Xiaoli[1];Wang, Yibing[1];Wang, Ping[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Sch Biotechnol, Biomed Nanotechnol Ctr,State Key Lab Bioreactor E, Shanghai 200237, Peoples R China;[2]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2018

卷号：85

起止页码：88

外文期刊名：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20175204574214);WOS:【SCI-EXPANDED(收录号:WOS:000428496400010)】；

基金：This work was supported by the National Natural Science Foundation of China (21303050, 31471659 and 21636003), and the Fundamental Research Funds for the Central Universities (222201514327). Authors thank the support from Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM).

语种：英文

外文关键词：Mesoporous silica nanoparticles; Curcumin; pH-responsive; Target drug delivery; Cancer therapy

摘要：Curcumin has attracted increasing attentions in recent years due to its promising anticancer activities. However, the hydrophobicity of curcumin has limited greatly its efficacy in clinical trials. In this study, folate (FA)-receptor targeting mesoporous silica nanoparticles that promise high loadings of curcumin via pH-sensitive Schiff base reactions were constructed and examined for targeted delivery of curcumin. Such nano-delivery system showed significantly improved stability and biocompatibility of curcumin under physiological conditions. Further investigations demonstrated that this nanocarrier had high values of drug loading efficiency (9.5%) and pH-responsive drug release property. Moreover, the particles could be efficiently internalized by FA-receptor-rich MCF-7 cells through the receptor-mediated endocytosis, whereas FA-receptor-poor HEK-293T normal cells showed much lower endocytosis of the nanoparticles under the same conditions. The in vitro cytotoxicity assay indicated that the curcumin-loaded nanoparticles exhibited significantly enhanced cytotoxicity against MCF-7 cell than HEK-293T cells because of the higher cellular uptake efficiency of nanocarriers. More broadly, this work demonstrates a new type of mesoporous silica nanocarrier particularly useful for targeted and controlled drug release applications.