文献类型：期刊文献

中文题名：丙硫菌唑的合成

英文题名：Synthesis of Prothioconazole

作者：王美娟[1];廖道华[1];曾仲武[2];李超[1];吴忠信[1];杨芳[1];师文娟[1]

机构：[1]华东理工大学制药工程系,上海200237;[2]浙江禾本农药化学有限公司,浙江温州325008

年份：2009

卷号：48

期号：3

起止页码：172

中文期刊名：农药

外文期刊名：Agrochemicals

收录：CSTPCD;;北大核心:【北大核心2008】；

语种：中文

中文关键词：丙硫菌唑;1-氯-1-氯乙酰基环丙烷;杀菌剂;合成

外文关键词：prothioconazole; 1-chloro-t-chloro-acetyl-cyclopropane; fungicide; synthesis

摘要：以1-氯-1-氯乙酰基环丙烷为起始原料经格式反应、缩合反应、硫的亲电加成反应合成了目标产物丙硫菌唑,缩合反应中用水代替DMF做溶剂,提高了产率,节约了成本。丙硫菌唑的总收率31.1%,含量99.3%。产物经1HNMR、MS进行了表征。
Prothioconazole was synthesized from 1-chloro-l-chloro-acetyl-cyclopropane via Grignard reaction, condensation and electrophilic addition of sulphur powder. The yield was increased and the cost was reduced while water was used as solvent instead of absolute DMF in the condensation. The total yield of prothioconazole was 31.1%, and the content was 99.3%. The products were determined by 1H NMR and MS.