文献类型：期刊文献

英文题名：Osteoinductive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia

作者：Liu, Yuanda[1,2,3];Wang, Jing[1,2,4];Jiang, Ming[1,2,3];Li, Xueyan[5];Zhang, Qinghao[1,2,3];He, Hongyan[1,2,3]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]Eye & Ent Hosp Fudan Univ, Dept stomatol, Shanghai 200031, Peoples R China

年份：2022

卷号：214

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20221111781800);WOS:【SCI-EXPANDED(收录号:WOS:000797917800003)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002) , the Fundamental Research Funds for the Central Univer-sities, State Administration of Foreign Experts Affairs P.R. China (Grant No. B14018) , National Key Research and Development Plan Strategic International Science and Technology Innovation Cooperation Key Projects (SQ2018YF020328) , National Natural Science Foundation of China (No. 31870953) , and Weigao Project of Chinese Academy of Sciences [2020] 005.

语种：英文

外文关键词：Hyperglycemia; Vascularization; Bone regeneration; Amorphous calcium phosphate; Biomineralization

摘要：In hyperglycemia patients, suffering from insufficient vascularization and vascular network lesion, tissue regeneration, such as bone repair, is limited and maybe delayed by the secondary injury and hyperglycemic microenvironment. Typically, dental therapies involving guided bone regeneration is facing a difficult condition in the patients with diabetes. In this study, a hybrid membrane was endowed with biomimetic function to create an angiogenesis-inductive microenvironment by calcium ion release to overcome the limitations of bone tissue regeneration in diabetic patients. Biomineralized calcium resource was Janus-structured onto the surface of hybrid hydrogel by layer-by-layer technique to enhance vascularization and improve the bone regeneration in this study. The release of calcium ions from mineralized phases was controlled by the solubility of inorganic phases and the degradation of gels, promoting HIF-1 alpha expression and creating a key role in angiogenesis stimulation. With highly enhanced calcium signaling and blood vessel formation, the hybrid hydrogel membranes improved the recruitment, proliferation and differentiation of mesenchymal stem cells and endothelial progenitors, confirmed by the enhancement of microvascular regeneration and new bone formation in the critical sized calvarial defect in diabetic model in vivo. Our study demonstrates a translational potential of hybrid hydrogels engineered with inorganic minerals for orthopedic applications in hyperglycemia.