文献类型：期刊文献

英文题名：Copper-Catalyzed Regioselective 1,4-Selenosulfonylation of 1,3-Enynes to Access Cyanoalkylsulfonylated Allenes

作者：He, Fu-Sheng[1,2];Bao, Ping[3,4];Yu, Feiyan[1,2];Zeng, Ling-Hui[5];Deng, Wei-Ping[3,4];Wu, Jie[1,2,6,7]

机构：[1]Taizhou Univ, Sch Pharmaceut & Mat Engn, 1139 Shifu Ave, Taizhou 318000, Peoples R China;[2]Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Taizhou 318000, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[5]Zhejiang Univ City Coll, Dept Pharmacol, 51 Huzhou Str, Hangzhou 310015, Peoples R China;[6]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China;[7]Henan Normal Univ, Sch Chem & Chem Engn, 6 East Jianshe Rd, Xinxiang 453007, Henan, Peoples R China

年份：2021

卷号：23

期号：19

起止页码：7472

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000704710800030)，CCR-EXPANDED(收录号:WOS:000704710800030)】；

基金：This work was supported by the National Natural Science Foundation of China (nos. 21871053, 22101199, and 22171206), the Natural Science Foundation of Zhejiang Province (LQ21B020002), the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2019R01005), and the Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD04).

语种：英文

摘要：By employing CuOAc as the catalyst, we realize a four-component reaction of 1,3 enynes, diselenides, DABCO. (SO2)(2), and cycloketone oxime esters, providing facile access to diverse cyanoalkylsulfonylated allenyl selenides in moderate to good yields. This reaction features high functional group tolerance and a broad substrate scope, enabling the regioselective, sequential formation of C-SO2 and C-Se bonds under mild reaction conditions. Moreover, the utility of this methodology is further illustrated through the late-stage functionalization of drug-based molecules.