文献类型：期刊文献

英文题名：Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway

作者：Zhou, Yingjun[1];Jia, Yuezhong[1];Xu, Nuo[1];Tang, Lihua[1];Chang, Yaning[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai, Peoples R China;[2]130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：250

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20233614691999);WOS:【SCI-EXPANDED(收录号:WOS:001059378000001)】；

基金：The authors are grateful for the support of Prof. Wei -Wang (Shanghai Jiaotong University, Shanghai, China) . The material in the graphical abstract was supported by Figdraw ( www.figdraw.com ) .

语种：英文

外文关键词：Obesity; Auricularia auricula-judae (Bull.); Polysaccharide; Gut microbiota; TLR4/JNK signaling pathway

摘要：Obesity has emerged as a crucial factor impacting people's lives, and gut microbiota disorders contribute to its development and progression. Auricularia auricula-judae (Bull.) polysaccharides (AAPs), a traditional functional food in Asia, exhibit potential anti-obesity effects. However, the specific mechanism still needs to be further confirmed. This study investigated the beneficial effects and specific mechanisms of AAPs on obesity. Firstly, AAPs showed significant improvements in overweight, insulin resistance, glucose and lipid metabolism disorders, and liver damage in obese mice. Additionally, AAPs ameliorated gut microbiota disorders, promoting the pro-liferation of beneficial bacteria like Lactobacillus and Roseburia, resulting in increased levels of SCFAs, folate, and cobalamin. Simultaneously, AAPs inhibited the growth of harmful bacteria, thereby protecting intestinal barrier function, improving endotoxemia, and decreasing the levels of inflammatory factors such as TNF-& alpha; and IL-6. Furthermore, AAPs can inhibit the TLR4/JNK signaling pathway while promoting the activation of AKT and AMPK. Importantly, our study underscored the pivotal role of gut microbiota in the anti-obesity effects of AAPs, as evidenced by fecal microbiota transplantation experiments. In conclusion, our findings elucidated that AAPs improve obesity by regulating gut microbiota and TLR4/JNK signaling pathway, offering novel perspectives for further conclusion the anti-obesity potential of AAPs.