文献类型：期刊文献

英文题名：Nanomaterial-based detection of circulating biomarkers to evaluate implants status: Monitoring of intervertebral disc degeneration

作者：Li, Chao[1];Qi, Longtao[1];Shao, Yang[2];Ye, Xinming[3];Wang, Yu[1]

机构：[1]Peking Univ First Hosp, Dept Orthopaed, 8 Xishiku St, Beijing 100034, Peoples R China;[2]Wuxi Tradit Chinese Med Hosp, Dept Orthopaed & Traumatol, Wuxi 214000, Jiangsu, Peoples R China;[3]East China Univ Sci & Technol, Sch Sports Sci & Engn, Shanghai 200237, Peoples R China

年份：2026

卷号：203

外文期刊名：TRAC-TRENDS IN ANALYTICAL CHEMISTRY

收录：;EI(收录号：20262620997260);WOS:【SCI-EXPANDED(收录号:WOS:001812276400001)】；

基金：This study was supported by the Beijing Changping District "Deputy Director of Science and Technology" Special Project (202501012012), the Beijing Natural Science Foundation (L244016), the National High Level Hospital Clinical Research Funding (2022-PUMCH-D-004), the Shandong Innovation and Startup Community of High-end Medical Apparatus and Instruments (2024-SGTTXM-002), the Technology Innovation Guidance Program of Shandong Province (YDZX2024096), and the Project of School-enterprise Cooperation (Approval No:L110-72301).

语种：英文

外文关键词：Intervertebral disc degeneration; Nanomaterials; Drug delivery systems; Tissue engineering; Exercise rehabilitation; Clinical translation

摘要：Long-term performance and safety of biomedical implants rely on timely detection of complications such as inflammation, infection, and implant failure. In this context, nanomaterial-based sensing platforms have emerged as powerful tools for the detection of circulating biomarkers indicative of implant status. This review highlights recent advances in nanomaterial-enabled analytical techniques for monitoring implant-related biomarkers in biofluids. These materials are widely integrated into electrochemical, optical, and plasmonic biosensors for rapid and minimally invasive detection. The review also examines relevant circulating biomarkers associated with implant performance, including inflammatory cytokines, infection markers, degradation byproducts, and tissue remodeling indicators. Emphasis is placed on the potential of multiplexed and real-time detection systems, particularly when combined with microfluidics and wearable technologies. Distinct from existing reviews limited to either general implant biosensing or isolated disc nanotherapeutics, this work provides a unified framework linking nanomaterial-based circulating biomarker detection for implant status monitoring to regenerative interventions and mechanobiology-guided rehabilitation, with specialized focus on the unique pathophysiological constraints of the intervertebral disc microenvironment. Despite significant progress, challenges remain in terms of reproducibility, long-term stability, and clinical translation. Overall, nanomaterial-based diagnostics represent a promising strategy for early detection of implant-related complications, enabling improved patient management and personalized healthcare.