文献类型：期刊文献

英文题名：A Point-of-Care Diagnostic Method Using Desiccation Patterns of Blood Sessile Droplets

作者：He, Hui[1,2];Xuan, Lujia[3];Lin, Yihe[1];Zhang, Min[4];Mou, Junjie[4];Chen, Ruoyang[4]

机构：[1]Zhejiang Sci Tech Univ, Ist Marangoni, Fash Design Coll, Hangzhou 311199, Peoples R China;[2]Zhejiang Prov Innovat Ctr Adv Text Technol, Shaoxing 312000, Peoples R China;[3]Zhejiang Sci Tech Univ, Sch Fash Design & Engn, Hangzhou 311199, Peoples R China;[4]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China

年份：2025

卷号：9

期号：3

外文期刊名：COLLOIDS AND INTERFACES

收录：WOS:【ESCI(收录号:WOS:001514746900001)】；

基金：This research was funded by Shanghai Pujiang Program (No. 23PJ1401800), the Science Foundation of Zhejiang Sci-Tech University (ZSTU) (No. 22192136-Y), and Scientific Research Fund of Zhejiang Provincial Education Department (No. Y202354119).

语种：英文

外文关键词：blood sessile droplet; desiccation patterns; health diagnosis; haematocrit level

摘要：The evaporation of a blood sessile droplet on a solid substrate generates distinctive desiccation patterns. These patterns have been identified as a potential tool for interpreting the pathological information of donors, since their morphological features encode pathological indicators linked to blood-related disorders. We collected two representative sets of blood samples from anonymous patients: healthy donors (normal haematocrit) and anaemia patients (low haematocrit). Our real-time observations of the morphological evolution during desiccation reveal distinct differences in pattern development. The macroscopic analysis indicates that blood sessile droplets from anaemia patients with abnormally low haematocrit levels experience divergent morphological trajectories, forming cracking patterns distinguishable from those of healthy donors. Our microscopic comparisons show that the blood desiccation patterns of healthy donors exhibit a longer coronal region and greater deposit coverage in the central region than those of anaemia patients. Our further analysis correlates these morphological variations to the effects of the haematocrit level of blood samples on material redistribution. This work proposes a facile strategy for health diagnostics through blood desiccation pattern analysis, highlighting its potential as a foundation for diagnostic platforms.