文献类型：期刊文献

英文题名：Hydroxyl-radical-specific cascade photogeneration for oxygen-chain photocatalytic therapy

作者：Liu, Qiang[1,2];Yan, Chenxu[1,2];Li, Xie[3];Huang, Haiyang[1,2];Fan, Zheyu[3];Zhang, Jizhan[1,2];Zhang, Weiwei[1,2,4];Shi, Ping[3];Zhao, Yuzheng[3];Guo, Zhiqian[1,2,3];Zhu, Wei-Hong[1,2,4]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat,Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr,Fronti, Joint Int Res Lab Precis Chem & Mol Engn,Inst Fine, Shanghai Key Lab Funct Mat Chem,Sch Chem & Mol Eng, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ctr, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm,State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Ctr Photosensit Chem Engn, State Key Lab Green Chem Engn & Ind Catalysis, Shanghai 200237, Peoples R China

年份：2026

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20262420880968);WOS:【SCI-EXPANDED(收录号:WOS:001787336500001)】；

基金：This work was supported by the National Key Research and Development Program (2023YFA1802000), NSFC/China (22225805, 32121005, 32394001, T2522013, and 22378122), Shanghai Science and Technology Innovation Action Plan (No. 23J21901600), Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), and Science and Technology Commission of Shanghai Municipality (grant No. 24DX1400200).

语种：英文

外文关键词：Chains - Mammals - Molecular oxygen - Photocatalytic activity - Photodynamic therapy - Reaction intermediates - Reactive oxygen species - Scaffolds - Scaffolds (biology)

摘要：The hydroxyl radical ((OH)-O-center dot), the most potent reactive oxygen species, plays a crucial role in photodynamic therapy (PDT). However, conventional photosensitizers (PSs) that produce (OH)-O-center dot through the classical Haber-Weiss pathway suffer from multistep/side reactions, short-lived intermediates, and O2 dependence, underscoring the demand for direct and selective (OH)-O-center dot photogeneration in biological tissues. Here, we report a de novo LQM scaffold core allowing the evolution of H2O into (OH)-O-center dot through an unprecedented "H2O-O2-(OH)-O-center dot" oxygen-chain cascade photochemical pathway. The acceptor relocation in D-pi-A featured PSs with long-range intramolecular charge transfer can regulate individual oxidation/reduction potentials and fully amplify the electron-hole separation, for the first time achieving (OH)-O-center dot-specific photogeneration independent of ambient O2. This generalizable molecular engineering method yields a palette of oxygen-chain PSs that spans the visible and second near-infrared ranges. Our LQM-based oxygen-chain photocatalytic therapy successfully improves therapeutic efficiency in living mice and addresses the long-standing hypoxic challenge of PDT. This study provides a full demonstration of our strategy for the rational design and streamlined PS discovery for (OH)-O-center dot-specific generation to push the limits of phototherapy in personalized treatment.