文献类型：期刊文献

英文题名：Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation

作者：He, Le[1,2];Meng, Fanying[3];Chen, Ran[3];Qin, Jinlong[2];Sun, Min[2];Fan, Zhen[2,3];Du, Jianzhong[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Dept Gynaecol & Obstet,Shanghai Key Lab Anesthesio, Shanghai 200434, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China

年份：2024

卷号：4

期号：11

起止页码：4162

外文期刊名：JACS AU

收录：WOS:【ESCI(收录号:WOS:001347012800001)】；

基金：This research was supported by National Natural Science Foundation of China (52222306, 22075212, 21925505, 22335005, and 22305177), Natural Science Foundation of Shanghai (20ZR1443200) and international scientific collaboration fund (23520710900) and Shanghai Rising-Star Program (Sailing, 23YF1433000) of Science and Technology Commission of Shanghai Municipality, the fellowship of China Postdoctoral Science Foundation (2022M720107, GZB20230517, 2024T170668), Shanghai "Super Postdoc" Incentive Plan of Shanghai Municipal Bureau of Human Resources and Social Security (2022568). J.D. is the recipient of National Science Fund for Distinguished Young Scholars.

语种：英文

外文关键词：intracellular polymerization; intracellular self-assembly; endogenous stimulus-triggering; exogenous stimulus-triggering; subcellular manipulation; bioactive materials

摘要：A living cell is an intricate machine that creates subregions to operate cell functions effectively. Subcellular dysfunction has been identified as a potential druggable target for successful drug design and therapy. The treatments based on intracellular polymerization, self-assembly, or transformation offer various advantages, including enhanced blood circulation of monomers, long-term drug delivery pharmacokinetics, low drug resistance, and the ability to target deep tissues and organelles. In this review, we discuss the latest developments of intracellular synthesis applied to precisely control cellular functions. First, we discuss the design and applications of endogenous and exogenous stimuli-triggered intracellular polymerization, self-assembly, and dynamic morphology transformation of biomolecules at the subcellular level. Second, we highlight the benefits of these strategies applied in cancer diagnosis and treatment and modulating cellular states or cell metabolism of living systems. Finally, we conclude the recent progress in this field, discuss future perspectives, analyze the challenges of the intracellular functional reactions for regulation, and find future opportunities.