文献类型：期刊文献

英文题名：Near-Infrared Cell-Permeable Hg²⁺-Selective Ratiometric Fluorescent Chemodosimeters and Fast Indicator Paper for MeHg⁺ Based on Tricarbocyanines

作者：Guo, Zhiqian[1,2];Zhu, Weihong[1,2];Zhu, Mingming[3];Wu, Xumeng[1,2];Tian, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Dept Gastroenterol, Renji Hosp, Shanghai Inst Digest Dis,Sch Med, Shanghai 200001, Peoples R China

年份：2010

卷号：16

期号：48

起止页码：14424

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000286484800030)】；

基金：This work was financially supported by the NSFC/China, the National Basic Research 973 Program (2006CB806200), the Program for Professor of Special Appointment at Shanghai Institutions of Higher Learning, the Shanghai Shuguang Project (07SG34), the Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP 200802510011), and the State Key Laboratory of Precision Spectroscopy (ECNU).

语种：英文

外文关键词：chemodosimeters; fluorescence; mercury; sensors; tricarbocyanines

摘要：Three tricarbocyanine dyes (IR-897, IR-877, and IR-925) with different thiourea substituents that function as dosimeter units through specific Hg2+-induced desulfurization have been demonstrated in a fast indicator paper for Hg2+ and MeHg+ ions. In comparison with available Hg2+-selective chemodosimeters, IR-897 and IR-877 show several advantages, such as convenient synthesis, very long wavelengths falling in the near-infrared (NIR) region (650-900 nm) with high molar extinction coefficients, a ratiometric response, and quite low disturbance with Ag+ and Cu2+ ions. They exhibit large redshifts, which result in a clear color change from deep blue to pea green that can be easily monitored by the naked eye for a convenient indicator paper. In emission spectra, they display a characteristic turn-off mode at 780 nm and turn-on mode at 830 nm with titration of Hg2+ ions. Remarkably, the signal/noise (S/N) ratio with other thiophilic metal ions (Ag+ and Cu2+) is greatly enhanced with ratiometric measurement of two channels: excitation spectra mode (I-810 nm/I-670 nm, monitored at 830 nm) and emission spectra mode (I-830 nm/I-780 nm, isosbestic absorption point at 730 nm as excitation). The distinct response is dependent upon the electron-donating effect of the thiourea substituents; that is, the stronger the electron-donating capability of the thiourea substituents, the faster the Hg2+-promoted cyclization. Additionally, experiments with living SW1116 cells show that these three tricarbocyanine dyes with low toxicity can exhibit special characteristics that are favorable for visualizing intracellular Hg2+ and MeHg+ ions in biological systems, including excellent membrane permeability, minimal interfering absorption and fluorescence from biological samples, low scattering, and deep penetration into tissues.