文献类型：期刊文献

中文题名：避蚊胺缓释霜剂的研制及其体外的经皮渗透

英文题名：Preparation of N,N-diethyl-m-toluamide sustained release cream and study its percutaneous permeability in vitro

作者：万晓璐[1];王苏莉[1];高峰[1];崔景斌[1]

机构：[1]华东理工大学药学院制药工程系,上海200237

年份：2007

卷号：22

期号：2

起止页码：174

中文期刊名：华西药学杂志

外文期刊名：West China Journal of Pharmaceutical Sciences

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：避蚊胺;交联聚乙烯吡咯烷酮;霜剂;高效液相色谱;Franz扩散池

外文关键词：N,N-diethy-m- toluanmide;PVPP;Cream;HPLC;Franz diffusion cells

摘要：目的制备避蚊胺缓释霜剂,并研究其体外经皮渗透情况。方法用正交筛选法优化避蚊胺缓释霜剂的处方,采用HPLC法测定避蚊胺的含量。利用Franz扩散池,进行体外经皮渗透试验。结果HPLC测定避蚊胺含量的回收率为101.6%,RSD=1.05%。避蚊胺缓释霜剂的体外渗透系数为0.0157 mg.cm-.2h-1,8 h累积渗透量为0.13 mg.cm-2。结论避蚊胺缓释霜剂中避蚊胺的体外经皮渗透明显减慢,累积渗透量大大减少。
OBJECTIVE To prepare N,N- diethyl - m - toluamide（DET） sustained release cream, and study on its percutaneous permeability in vitro. METHODS DET sustained release cream was screened and optimized by orthogonal - designed method. DET was determined by HPLC method. The percutaneous tests were carried out in vitro by using Franz diffusion cells. RESULTS The average recovery and RSD of DET were 101.6% and 1.05%, respectively. The permeability coefficient and cumulative permeation quantity（8 h） of DET sustained release cream were 0. 0157 mg.cm^-2·h^-1 and 0.13 mg·cm^-2, respectively. CONCLUSION The permeation rate and permeation quantity of DET from DET sustained release cream are decreased obviously.