文献类型：期刊文献

英文题名：Remarkable Antibacterial Activity of Reduced Graphene Oxide Functionalized by Copper Ions

作者：Tu, Yusong[1,2];Li, Pei[3];Sun, Jiajia[1];Jiang, Jie[4,5];Dai, Fangfang[6];Li, Chengzhang[3];Wu, Yuanyan[1];Chen, Liang[6];Shi, Guosheng[7];Tan, Yanwen[3];Fang, Haiping[4,5,8]

机构：[1]Yangzhou Univ, Coll Phys Sci & Technol, Yangzhou 225009, Jiangsu, Peoples R China;[2]East China Normal Univ, Sch Phys & Elect Sci, Minist Educ, Key Lab Polar Mat & Devices, Shanghai 200241, Peoples R China;[3]Fudan Univ, Dept Phys, Multiscale Res Inst Complex Syst, State Key Lab Surface Phys, Shanghai 200433, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China;[5]Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China;[6]Zhejiang A&F Univ, Dept Opt Engn, Linan 311300, Peoples R China;[7]Shanghai Univ, Shanghai Appl Radiat Inst, Shanghai 200444, Peoples R China;[8]East China Univ Sci & Technol, Sch Sci, Shanghai 200237, Peoples R China

年份：2021

卷号：31

期号：13

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20210509872402);WOS:【SCI-EXPANDED(收录号:WOS:000608837400001)】；

基金：Y.T. and P.L. contributed equally to this work. The authors thank Jianjun Jiang for preliminary testing calculations. The supports are from NNSFC (Nos. 12075201, 12074341, 11675138, U1832150, 21773039), the National Science Fund for Outstanding Young Scholars (No. 11722548), Science and Technology Planning Project of Jiangsu Province (BK20201428), the Special Program for Applied Research on Supercomputation of the NSFC-Guangdong Joint Fund (the second phase), Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01), SCI & TECH Project (No.20ZR1405800), and ZJLab.

语种：英文

外文关键词：avoiding environmental hazards; density functional theory calculations; reduced graphene oxide; selective antibacterial activity

摘要：Despite long-term efforts for exploring antibacterial agents or drugs, potentiating antibacterial activity and meanwhile minimizing toxicity to the environment remains a challenge. Here, it is experimentally shown that the functionality of reduced graphene oxide (rGO) through copper ions displays selective antibacterial activity that is significantly stronger than that of rGO itself and no toxicity to mammalian cells. Remarkably, this antibacterial activity is two-orders-of-magnitude greater than the activity of its surrounding copper ions. It is demonstrated that rGO is functionalized through the cation-pi interaction to massively adsorb copper ions to form a rGO-copper composite and result in an extremely low concentration level of surrounding copper ions (less than approximate to 0.5 mu m). These copper ions on rGO are positively charged and strongly interact with negatively charged bacterial cells to selectively achieve antibacterial activity, while rGO exhibits the functionality to not only actuate rapid delivery of copper ions and massive assembly onto bacterial cells but also result in the valence shift in the copper ions from Cu2+ into Cu+, which greatly enhances the antibacterial activity. Notably, this rGO functionality through cation-pi interaction with copper ions can similarly achieve algaecidal activity but does not exert cytotoxicity against neutrally charged mammalian cells.