文献类型：期刊文献

英文题名：Synthesis of Glutathione-Responsive Cyclomatrix Polyphosphazene for Multimodal Theranostic Nanodrug Delivery

作者：Li, Jinjin[1];Liu, Ruyue[1];Zhang, Bingyan[1];Bai, Feifei[1];Zhao, Ling[1,2];Xi, Zhenhao[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：5

期号：7

起止页码：4993

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;EI(收录号：20232714340562);WOS:【SCI-EXPANDED(收录号:WOS:001009548000001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 21978089), the Program of Shanghai Academic/Technology Researcher Leader (Grant No. 21XD1433000), the Program of Shanghai Rising-Star (Grant No. 22QA1402800), the Fundamental Research Funds for the Central Universities (Grant No. 22221818010), the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-21C04), and the 111 Project (Grant No. B20031).

语种：英文

外文关键词：cyclomatrix polyphosphazene; genistein; IR780; self-framed delivery system; multimodal therapy

摘要：In this work, a multimodal (chemotherapeutic/photodynamic/photothermal)theranostic nanodrug delivery platform was developed based on thesynergetic action of self-framed polyphosphazene prodrug and heptamethinecyanine dye IR-780. First, an electronegative glutathione (GSH)-responsivepolyphosphazene prodrug abbreviated as HGEH was prepared via multicomponentcondensation reaction of genistein (GEN), bis-(4-hydroxyphenyl)-disulfide,and hexachlorocyclotriphosphazene. The particle size of drug (GEN)-containingHGEH nanoparticles is adjustable. Subsequently, cationic near-infraredphotosensitizer IR-780 was adsorbed onto the electron-rich HGEH toobtain the multimodal theranostic nanodrug delivery platform HGEH-IR780.The platform was demonstrated to retain high stability in avoidingdrug leakage and enable controlled drug release in response to thetumor microenvironment, in which a higher GSH concentration exists.The in vitro experiments show that HGEH-IR780 undergoes photothermaland photodynamic processes to concurrently generate heat and reactiveoxygen species for efficiently killing mouse breast cancer cells (4T1)upon exposure to a single-bandwidth near-infrared laser (808 nm).Specifically, HGEH-IR780 inhibits 4T1 cells by up to 80% at a concentrationof 100 mu g/mL. The as-developed HGEH-IR780 exhibits promisingresults in GSH-responsive anticancer activity and photodynamic/photothermaltherapy, which provides a reference for the construction of the polyphenolflavonoid multimodal therapeutic nanoplatform.