文献类型：期刊文献

英文题名：A high-throughput screening method of bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products by ultra-high performance liquid chromatography-tandem mass spectrometry

作者：Cheng, Yan[1,2];Nie, Xue-mei[1];Wu, Han-qiu[1];Hong, Yun-he[1];Yang, Bing-cheng[2];Liu, Tong[1];Zhao, Dan[1];Wang, Jian-feng[1];Yao, Gui-hong[1];Zhang, Feng[1]

机构：[1]Chinese Acad Inspect & Quarantine, Inst Food Safety, 11 Ronghua South Rd, Beijing 100176, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2017

卷号：950

起止页码：98

外文期刊名：ANALYTICA CHIMICA ACTA

收录：;EI(收录号：20164903093855);WOS:【SCI-EXPANDED(收录号:WOS:000390629500011)】；

基金：The authors gratefully acknowledge financial support from the project of Ministry of Science and Technology of the People's Republic of China (No.2016YFD0401103 and No.2016YFF0203903).

语种：英文

外文关键词：Bisphenols; Bisphenols digycidyl ethers and their derivatives; Ultra-high performance liquid chromatography-tandem mass spectrometry; High throughput; QuEChERS

摘要：A simple and universal analytical method based on ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for high throughput screening of 21 bisphenols, bisphenols digycidyl ethers and their derivatives in dairy products was developed. Response Surface Methodology (RSM) was used to optimize sample preparation conditions based on a quick, easy, cheap, effective, rugged and safe (QuEChERS) method. The analytes were extracted by using 15 mL acetonitrile with 1% acetic acid, and the extracts were further purified by using 190 mg of C18 and 390 mg of PSA. The extracts were analyzed by UHPLC-MS/MS with electrospray ionization (ESI) source. Linearity was assessed by using matrix-matched standard calibration and good correlation coefficients (r(2) > 0.99) were obtained. The limits of quantitation (LOQs) for the analytes ranged from 0.02 to 5 mu g kg(-1). The extraction recoveries were in a range of 88.2%-108.2%. Good method reproducibility in terms of intra- and inter-day precision was observed, yielding relative standard deviations (RSDs) less than 8.9% and 9.9%, respectively. The validation method results revealed that the proposed method was sensitive and reliable. Finally, this method was successfully applied to dairy product analysis. (C) 2016 Elsevier B.V. All rights reserved.