文献类型：期刊文献

中文题名：新型腙类衍生物的合成及其生物活性

英文题名：Synthesis and Bioactivity of a Series of Novel Hydrazone Derivatives

作者：汪飞[1];曹瑾[2];袁莉萍[2];郭庆铭[2];倪长春[2];沈宙[2];张一宾[2]

机构：[1]华东理工大学药学院,上海200237;[2]上海市农药研究所,上海200032

年份：2006

卷号：8

期号：2

起止页码：176

中文期刊名：农药学学报

外文期刊名：Chinese Journal of Pesticide Science

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

基金：国家"十五"科技攻关计划(2004BA308A22-3);上海市科技攻关计划(034319251);国家重点基础研究发展计划("973"计划)资助项目2003CB114401)

语种：中文

中文关键词：酰化反应;芳基丙酮腙;合成;生物活性

外文关键词：acylation; hydrazone; synthesis; bioactivity

摘要：利用3-（N-甲基-N-甲氧基氨基）-1-芳基-1-丙酮腙与酰氯反应，合成了14个新型N-酰基-3-（N-甲基-N-甲氧基氨基）-1-芳基-1-丙酮腙化合物，其化学结构经^1H核磁共振和元素分析确证。初步的生物活性测试结果表明，部分化合物在50mg／L时对淡色库蚊Culex pipiens pallens的致死率为95％-100％；化合物c7在1000mg／L时对粘虫Leucania separata Walke的致死率达100％。
In search of novel pesticide compound with high bioactivity, fourteen new N-3-（N-methoxy- N-methyl-amino）-1-arly-propylidene-hydrazazide derivatives have been designed and synthesized by the reaction of N-[3-hydrazono-propyl]-O, N-dimethyl-hydroxylamine with different acyl chlorides. Their structures have been confirmed by ^1H NMR and elemental analysis. The preliminary biological activity showed that some compounds possessed insecticidal activities against Culex pipiens pallens and Leucania separata Walke. The mortality ratio of some compounds against C. pipiens pallens coqillett were 95% - 100% at concentration of 50 mg/L. The mortality ratio of c7 against L. separata was 100% at 1 000 mg/L.