文献类型：期刊文献

英文题名：A water-stable phosphorescent probe for doxorubicin detection by phosphorescence resonance energy transfer

作者：Wu, Da Jun[1];Liang, Li Ya[1];Shi, Yichen[2];Gao, Ya Ting[1];Chang, Shuai[3];Lv, Jian[1];Qian, Ruo Can[1];Li, Da Wei[1];Bin Chen, Bin[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai World Foreign Language Acad, Baihua St 400, Shanghai, Peoples R China;[3]Shenzhen Polytech Univ, Hoffmann Inst Adv Mat, 7098 Liuxian Blvd, Shenzhen 518055, Peoples R China

年份：2025

卷号：437

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20251418187933);WOS:【SCI-EXPANDED(收录号:WOS:001465186900001)】；

基金：The authors appreciate the financial support from the National Natural Science Foundation of China (22176058) , Science and Tech-nology Commission of Shanghai Municipality (22ZR1416800 and 23ZR1416100) , the Program of Introducing Talents of Discipline to Universities (B16017) , and the Fundamental Research Funds for the Central Universities (222201717003) . We thank the Research Center of Analysis and Test of East China University of Science and Technology for help with the characterization.

语种：英文

外文关键词：Water-stable phosphorescent probes; Metal-organic coordination; Phosphorescence resonance energy transfer; Doxorubicin detection

摘要：Phosphorescent sensing probes have attracted considerable attention due to their ability to eliminate autofluorescence interference in biological samples. However, constructing water-stable phosphorescent materials remains a significant challenge because of water-quenched phosphorescence (phos.) property. Herein, a facile one-step thermal polymerization is proposed to synthesize aluminium/4-chlorobenzoicacid phosphorescent materials (Al/PCBA-PMs). The obtained Al/PCBA-PMs have two phos. emissions at 438 nm and 515 nm, respectively, with a lifetime of 83.67 ms. Importantly, the Al/PCBA-PMs show good water-stable phosphorescent property, and the introduction of water can cause a change in phosphorescent color of Al/PCBA-PMs from blue to green, but which has only a small impact on phosphorescent intensity and lifetime. Furthermore, a system of phos. resonance energy transfer (PhRET) can be constructed where Al/PCBA-PMs act as phosphorescent donors and doxorubicin (DOX) serves as fluorescent acceptors. This PhRET system has a high efficiency of 44.25 %, which can achieve the direct and precise determination of DOX in biological samples with strong autofluorescence, with a linear range of 0 -100 mu M. This work proposes a powerful strategy for constructing waterstable phosphorescent probes and develops a new type of PhRET system to achieve precise phosphorescent detection in biological samples.