文献类型：期刊文献

英文题名：NIS/PhI(OAc)2-Mediated Diamination/Oxidation of N-Alkenyl Formamidines: Facile Synthesis of Fused Tricyclic Ureas

作者：Zhang, Jun[1,2];Wu, Weijie[1,2];Zhang, Xuejun[1,2];Zhang, Gengtao[1,2];Xu, Sheng[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：10

期号：3

起止页码：544

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20150900573708);WOS:【SCI-EXPANDED(收录号:WOS:000349959500006)】；

基金：Financial support from Shanghai Pujiang Talent Program (11J1402500), the Shanghai Municipal Committee of Science and Technology (11JC1402600), National Basic Research Program of China (973)-2010CB833302, and the National Natural Science Foundation of China for financial support (21171056, u1162111 and u1362111) is greatly acknowledged.

语种：英文

外文关键词：alkenes; aminoamidiniumation; deamination; N-iodosuccinimide; oxidation

摘要：Facile synthesis of bicyclic ureas by NIS/PhI(OAc)(2)-mediated diamination/oxidation of N-alkenyl formamidines is reported. Bulky aromatic groups such as 2,6-diisopropylphenyl and mesityl and alkyl groups were tolerated towards the process. Several control experiments have been performed, and the reaction outcomes indicate that the oxidation process is probably concerted with the diamination cyclization, and succinimide generated from NIS-mediated aminoamidiniumation step promoted the PhI(OAc)(2)-mediated oxidation step. The new methodology provides an efficient method for the synthesis of fused tricyclic ureas.