文献类型：期刊文献

英文题名：Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones

作者：Sun, Xiaohua[1];Fei, Jie[1];Zou, Chuncheng[1];Lu, Min[1];Ye, Jinxing[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Shanghai Key Lab New Drug Design, Engn Res Ctr Pharmaceut Proc Chem,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：6

期号：108

起止页码：106676

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20164703048707);WOS:【SCI-EXPANDED(收录号:WOS:000389330700073)】；

基金：This work was partially supported by National Natural Science Foundation of China (21272068, 21572056), Program for New Century Excellent Talents in University (NCET-13-0800) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Amines

摘要：Highly enantioselective 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolnethiones have been realized by employing a cinchona-based primary amine catalyst. This method displays a broad substrate scope and provides a simple and highly effective way to achieve the chiral spiro[thiopyranoindole-cyclohexanone] scaffold.