文献类型：期刊文献

英文题名：Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

作者：Dong, Lei[1,2];Zang, Yi[3];Zhou, Dan[1,2,3];He, Xiao-Peng[1,2];Chen, Guo-Rong[1,2];James, Tony D.[4];Li, Jia[3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2015

卷号：51

期号：59

起止页码：11852

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000357804800027)】；

基金：This research is supported by the 973 project (2013CB733700), the National Science Fund for Distinguished Young Scholars (81125023), the National Natural Science Foundation of China (21202045, 91213303), the Program of Shanghai Subject Chief Scientist (13XD1404300), the Key Project of Shanghai Science and Technology Commission (13NM1400900) and the Fundamental Research Funds for Central Universities (222201414010). The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities.

语种：英文

摘要：With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.