文献类型：期刊文献

英文题名：Triple cell-responsive nanogels for delivery of drug into cancer cells

作者：Xu, Xin[1,2];Wang, Xiaofeng[5];Luo, Wei[1,2];Qian, Qihong[1,2];Li, Qian[5];Han, Baosan[4];Li, Yulin[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China;[4]Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gen Surg,Lab Gen Surg, Kongjiang Rd 1665, Shanghai 200092, Peoples R China;[5]Zhengzhou Univ, Sch Mech & Engn Sci, Natl Ctr Int Res Micronano Molding Technol, Zhengzhou 450002, Henan, Peoples R China

年份：2018

卷号：163

起止页码：362

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20180304647785);WOS:【SCI-EXPANDED(收录号:WOS:000427217300042)】；

基金：The authors appreciated the support of the Shanghai International Cooperation Program (15520721200). The opening financial grant from National Center for International Research of Micro nano Molding Technology & Key Laboratory for Micro Molding Technology of Henan Province (MMT2016-04) was thanked. The Public Projects of Zhejiang Province(2015C31040) and of Zhejiang Province Department of Education (Y201328505) were also acknowledged. The authors thank Dr. Dina Maciel to polish this work in English language.

语种：英文

外文关键词：Cell-responsive nanogels; Alginate; Poly(N-isopropylacrylamide); Temperature-induced cell death; Drug delivery

摘要：In this report, biocompatible nanogels with multi cell-responsiveness (thermo-, pH- and reduction) were fabricated by in situ cross-linking of alginate (AG) using cystamine (Cys) as a cross-linker through an emulsion approach, in the presence of a thermosensitive polymer, poly(N-isopropylacrylamide) (PNIPAM). The AG/PNIPAM nanogels exhibited an abrupt swelling upon temperature increase from 37 to 25 degrees C under physiological conditions (497 +/- 258 nm at 29 degrees C and 147 48 nm at 37 degrees C). The nanogels were easily taken up by cancer cells at high temperature, where temperature variation could induce toxicity against cancer cells. Furthermore, the accelerated release under reducible and acidic microenvironments inside cells, together their thermosensitivity, made the nanogels selectively deliver drug intracellulary to exert a synergistical anticancer efficacy, potentiating therir high promise for drug delivery application. (C) 2018 Elsevier B.V. All rights reserved.