文献类型：期刊文献

中文题名：肝素化聚氨酯作为药物洗脱支架涂层材料

英文题名：Heparin-Immobilized Polyurethane as Potential Coating Material for Coronary Stents

作者：龚飞荣[1];赵燕超[1];戎宗明[2];程树军[1];杲云[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237;[2]华东理工大学化学与分子工程学院,上海200237

年份：2010

期号：2

起止页码：228

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家863项目(2007AA02Z450)

语种：中文

中文关键词：聚氨酯;支架;涂层;血栓;再狭窄

外文关键词：polyurethane; stent; coating; thrombosis; restenosis

摘要：以聚碳酸酯二元醇(PCDL)为软段,4,4′-二苯基亚甲基二异氰酸酯(MDI)为硬段,二羟甲基丙酸(bis-MPA)为扩链剂合成了侧链含羧基的聚碳酸酯型聚氨酯。聚氨酯表面经1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐(EDAC)活化后接枝肝素分子,得到肝素化聚氨酯材料。经测定,材料表面肝素接枝量达到1.92μg/cm2,聚合物亲水性明显提高,体外蛋白质黏附实验显示肝素化聚氨酯抑制蛋白质吸附的能力较肝素化之前明显提高。动物实验表明肝素化聚氨酯作为支架涂层材料对血管壁的炎性刺激明显低于未肝素化材料,有望成为一种理想的冠状动脉支架涂层材料。
Polycarbonate polyurethane with pendant carboxyl groups were successfully synthesized using polycarbonate diols（PCDL） as soft segments,diphenylmethane diisocyanate（MDI） as hard segments,and 2,2-bis（hydroxymethyl） propionic acid（bis-MPA） as chain extenders.Heparin was immobilized onto the surface of polyurethane through a covalent reaction in the presence of 1-（3-dimethylaminopropyl）3-ethylcarbodiimide hydrochloride（EDAC）.The surface exposed heparin content was measured to be 1.92 μg/cm^2 and the hydrophilicity of the heparinized polymer was greatly improved.The capability of adsorbing protein decreased after heparin immobilization.Animal implantation results showed good biocompatibility of the heparin immobilized material and this novel polymer could be applied as a potential coating material for coronary stents with lower inflammatory reaction formation than the original material.