文献类型：期刊文献

英文题名：Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid

作者：Huang, He[1];Yu, Chenguang[1];Li, Xiangmin[1,2,3];Zhang, Yongqiang[2,3];Zhang, Yueteng[1];Chen, Xiaobei[2,3];Mariano, Patrick S.[1];Xie, Hexin[2,3];Wang, Wei[1,2,3]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]East China Univ Sci Technol, Sch Pharm, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：56

期号：28

起止页码：8201

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20172603860159);WOS:【SCI-EXPANDED(收录号:WOS:000404140900029)，CCR-EXPANDED(收录号:WOS:000404140900029)】；

基金：Financial support of this research from the NSF (CHE-1565085) ACS-PRF (57164-ND1) and the National Science Foundation of China (21372073 and 21572055) is gratefully acknowledged.

语种：英文

外文关键词：arenes; boron; formylation; organocatalysis; synthetic methods

摘要：Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity is engineered into the alpha-amino-acid-forming Petasis reaction occurring between aryl boronic acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and alpha,beta-unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the new synthetic strategy.