文献类型：期刊文献

英文题名：Pillar[5]arene-Based Switched Supramolecular Photosensitizer for Self-Amplified and pH-Activated Photodynamic Therapy

作者：Huang, Baoxuan[1];Wang, Peng[1];Ouyang, Yingjie[1];Pang, Ruiqi[1];Liu, Siyi[1];Hong, Chenyu[1];Ma, Shaohua[1];Gao, Yun[1];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：12

期号：37

起止页码：41038

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20204309371056);WOS:【SCI-EXPANDED(收录号:WOS:000572965700006)】；

基金：The authors thank the financial support by the National Natural Science Foundation of China (nos. 51803058 and 21875063), the Fundamental Research Funds for the Central Universities (no. 222201814018), and the Project of Science and Technology Commission of Shanghai Municipality (no. 19DZ2330400).

语种：英文

外文关键词：supramolecular chemistry; photodynamic therapy; pillararene; host-guess interaction; porphyrin

摘要：Photodynamic therapy (PDT) has emerged as a promising and spatiotemporally controllable cancer treatment modality. However, serious skin photosensitization during the PDT process limits the clinical application of PDT. Thus, the construction of "smart" and multifunctional photosensitizers has attracted substantial interest. Herein, we develop a mitochondria-targeting and pH-switched hybrid supramolecular photosensitizer by the host-guest interaction. The PDT efficacy of supramolecular photosensitizers can be quenched by the Forster resonance energy transfer (FRET) effect during long circulation and activated by the dissociation of supramolecular photosensitizers in an acidic tumor microenvironment, benefitting from the dynamic feature of the host-guest interaction and pH responsiveness of the water-soluble pillar[5]arene on gold nanoparticles. The rational integration of mitochondria-targeting and reductive glutathione (GSH) elimination in the hybrid switchable supramolecular photosensitizer prolongs the lifetime of reactive oxygen species generated in the PDT near mitochondria and further amplifies the PDT efficacy. Thus, the facile and versatile construction of switchable supramolecular photosensitizer offers not only the targeted and precise phototherapy but also high therapeutic efficacy, which would provide a new path for the clinic application of PDT.