文献类型：期刊文献

英文题名：Facile construction of a dual pH/redox-responsive nanopesticide for precise control of Fusarium graminearum with enhanced biosafety

作者：Sun, Li[1];Xing, Demei[1];Li, Zhen[2];Gao, Yanyan[1];Peng, Yue[1];Zhang, Jiale[1];Gao, Yue[1];Gong, Ruihan[1];Zhou, Cong[1];Cheng, Jiagao[1,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Yangzhou Univ, Sch Plant Protect, Yangzhou 225009, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China

年份：2026

卷号：540

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20262120753175);WOS:【SCI-EXPANDED(收录号:WOS:001780828500001)】；

基金：This work was supported by the National Key Research and Devel-opment Program (2022YFD1700500) , and the National Natural Science Foundation of China (22477029) .

语种：英文

外文关键词：Nanopesticide; Metal-organic frameworks; Metal-phenolic network; Environmentally responsive; Fusarium graminearum; Biosafety

摘要：Environmentally responsive nano-pesticide systems enable precise and controllable pesticide release but typically require complex, multi-step fabrication. Inspired by the "Making the complicated simple" concept, we developed a streamlined one-step strategy in which carrier assembly, pesticide loading, and intelligent gating proceed in a synchronized manner to construct a pH/redox dual-responsive nanopesticide delivery system (PRO@ZnMOF@MPN) for long-lasting control of Fusarium graminearum. This system integrates a zinc-based metal-organic framework (ZnMOF) with an in situ assembled tannic acid (TA)-Fe3+ metal-phenolic network (MPN), enabling efficient incorporation of prochloraz (PRO). Structural and physicochemical characterizations demonstrate the successful construction of PRO@ZnMOF@MPN, featuring a PRO loading capacity of 19.52% and a uniform MPN shell. The synergistic protection provided by the ZnMOF core and MPN shell markedly enhances photostability and enables pH and redox-triggered release, matching the microenvironmental characteristics of pathogen-infected sites. The abundant phenolic hydroxyl groups of MPN improve leaf wettability and enhance droplet deposition on wheat leaves. PRO@ZnMOF@MPN exhibits superior and sustained antifungal activity against Fusarium graminearum relative to the commercial emulsifiable concentrate (PRO EC), with persistent inhibition of mycelial growth (EC50 = 0.395 mg/L at 96 h) and in vivo control efficacy maintained above 50% across all applied concentrations at 10 d. Biosafety assessments reveal low toxicity toward zebrafish, Daphnia magna, earthworms, and soil microbial communities, negligible effects on wheat growth, and reduced cytotoxicity toward human hepatocytes (L02). This work establishes a facile and integrative paradigm for constructing efficient, environmentally responsive, and eco-friendly nanopesticide delivery systems.