文献类型：期刊文献

英文题名：Palladium-catalyzed dehydrogenation of α-cyclohexene-substituted nitriles to α-aryl nitriles

作者：Zhao, Yinglin[1];Zhang, Zhida[1];Qi, Zehuan[1];Liu, Renhua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Engn Res Ctr Pharmaceut Proc Chem, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2024

卷号：60

期号：25

起止页码：3425

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20241115720058);WOS:【SCI-EXPANDED(收录号:WOS:001178338700001)，CCR-EXPANDED(收录号:WOS:001178338700001)】；

语种：英文

外文关键词：Dehydrogenation - Palladium

摘要：The development of a practical, inexpensive, and cyanide-free method for synthesizing alpha-aryl nitriles remains a challenging goal in synthetic chemistry. Here, we report an approach for synthesizing alpha-aryl nitriles toward achieving this goal, by which alpha-cyclohexenyl acetonitriles and alpha-cyclohexenyl alkenyl nitriles are dehydrogenated to alpha-aryl nitriles. Cyanide-free: synthesis of alpha-aryl nitriles from cyclohexanones and cyanoacetic acid by condensation and dehydrogenation.