文献类型：期刊文献

英文题名：A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing

作者：Yang, Jie[1,2];Ding, Ao[1];Zhou, Jia-Le[1];Yan, Bing-Yong[1];Gu, Zhen[1];Wang, Hui-Feng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Smart Mfg Energy Chem Proc, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：13

期号：10

外文期刊名：BIOSENSORS-BASEL

收录：;EI(收录号：20234414983350);WOS:【SCI-EXPANDED(收录号:WOS:001094219300001)】；

基金：This research was funded by the National Key R & D Program of China (2021YFC2101101).

语种：英文

外文关键词：capsule sensor; solid-contact ion-selective electrode; in situ monitoring; multichannel; wireless sensor network; cell culture

摘要：Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K+, NH4+, Na+, Ca2+, and Mg2+ based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media.