文献类型：期刊文献

英文题名：Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease

作者：Tong, Hongjuan[1];Lou, Kaiyan[1];Wang, Wei[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioengn Reactor, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2015

卷号：5

期号：1

起止页码：25

外文期刊名：ACTA PHARMACEUTICA SINICA B

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000360008000003)】；

语种：英文

外文关键词：Alzheiimer's disease; Blood-brain barrier; Fluoresence probe; Near-infrared fluorescence; Optical imaging; Amyloid-beta plagues

摘要：One of the early pathological hallmarks of Alzheimer's disease (AD) is the deposition of amyloid-beta (A beta) plaques in the brain. There has been a tremendous interest in the development of A beta plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of A beta plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF A beta probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Median, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.