文献类型：期刊文献

英文题名：A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

作者：Zhao, Wenru[1];Zhang, Hongti[1];He, Qianjun[2];Li, Yongsheng[1];Gu, Jinlou[1];Li, Liang[1];Li, Hua[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Adv Funct Mat Lab, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2011

卷号：47

期号：33

起止页码：9459

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000293648200053)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 21001043 and No. 51072053), the Natural Science Foundation of Shanghai (Grant No. 10ZR1407500), the Fundamental Research Funds for the Central Universities (Grant No. WD0911012 and No. WK1013001), the New Century Excellent Talents in University (Grant No. NCET-10-0379), and the Program for Changjiang Scholars and Innovative Research Team in University (Grant No. IRT0825).

语种：英文

摘要：A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.